Phase I Safety and Immunogenicity Study of a Candidate Meningococcal Disease Vaccine Based on Neisseria lactamica Outer Membrane Vesicles
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چکیده
منابع مشابه
Study of the immunogenicity of outer membrane protein A (ompA) gene from Acinetobacter baumannii as DNA vaccine candidate in vivo
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A novel approach for development of a meningococcal group B vaccine has been developed. This approach , which uses vesicles or blebs of the meningococcal outer membrane prepared without exposure to detergent or denaturing solvents, allows the outer membrane antigens to be presented to the immune system in their natural conformation and membrane environment. Two strategies for using these native...
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Carriage of non-serogroupable Neisseria meningitidis or Neisseria lactamica induces antibodies protective against meningococcal disease. Antibodies directed against outer membrane proteins are bactericidal and the serotype and subtype outer membrane protein antigens are being examined for their value as vaccine candidates for serogroup B disease. The aim of this study was to examine the effect ...
متن کاملNeisseria lactamica protects against experimental meningococcal infection.
Immunological and epidemiological evidence suggests that the development of natural immunity to meningococcal disease results from colonization of the nasopharynx by commensal Neisseria spp., particularly with N. lactamica. We report here that immunization with N. lactamica killed whole cells, outer membrane vesicles, or outer membrane protein (OMP) pools and protected mice against lethal chall...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2009
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cvi.00118-09